Walt and Jesse
51 episodes of Breaking Bad carry this thread, 2d 3h in all — 49 of them are in The Essentials.
In airing order

A high-school chemistry teacher (Bryan Cranston) is diagnosed with a deadly cancer, so he puts his expertise to use and teams with an ex-student (Aaron Paul) to manufacture top-grade crystal meth in hopes of providing for his family after he's gone.

After the accident in the desert, Walter and Jesse need to dispose of the unfortunate mess in their rolling lab of an RV, and Skyler begins to suspect that Walter and Jesse are involved in some mysterious goings-on.

Walter and Jesse fight about the latter's drug use, so he leaves, forcing Walter to deal with their captive, Krazy-8 (Max Arciniega); Hank uses scared-straight tactics with Walter Jr. when his aunt suspects he's smoking pot; Skyler is furious when Walter stays away from home.

Walter, in the throes of his chemotherapy treatment and needing money more than ever, agrees to cook more crystal meth with Jesse; Skinny Pete hooks Jesse up with an important new contact, while the DEA intensifies its investigation of Albuquerque's new drug kingpin.

Walter and Jesse do business with a new partner-in-crime, but immediately run into "production problems," which necessitates a nearly impossible mission to knock off a chemical-supply house. Meanwhile, Marie throws a baby shower for Skyler and presents her with an unusual gift that shows a different side of the aunt-to-be.

Season 2 kicks off with Walt and Jesse once again bearing witness to Tuco's incendiary disposition, which leads them to the conclusion that it's time to put an end to their business dealings with him. But the question is how. Meanwhile, Hank serves as a go-between for estranged sisters Skyler and Marie.

Trying to dissociate themselves from the volatile Tuco takes a bad turn when Walt and Jesse get trapped with the dealer, and Skyler, worried about her missing husband, receives comfort from her sister and brother-in-law. Hank, meanwhile, pays a business call on Jesse's mother.

Walt and Jesse attempt to cover their tracks and distance themselves from Tuco, but they soon find that business is taking a hit along with their financial situation. Meanwhile, Hank and his DEA investigation into the meth ring get a major break that just might put Walt and Jesse in their crosshairs.

Despite Walt's attempt to reconnect with the family, a suspicious Skyler keeps him at arm's length and worries about what he's been up to while he's been away from the house; Jesse finds himself on the streets once again and struggles to improve his lot in life.

Hank deals with some lingering aftereffects from his confrontation with Tuco; bills are piling up at the White house and tensions are beginning to run high; Jesse organizes a crew of dealers to take their product to the streets.

Walt returns to teaching at the high school; when Skinny Pete gets taken advantage of and ripped off, Jesse steps in, but bites off more than he can chew; Skyler takes the opportunity to show her appreciation for Gretchen's kindness in picking up the tab for Walt's treatments.

Walt and Jesse contemplate an expansion of their business; Hank experiences a hassle in El Paso as he tries to adapt to his new coworkers; Skyler's new job opportunity leads to her reconnecting with an ex-colleague; and Jesse interacts with his new landlady.

Badger's brush with the law leads Walt and Jesse to call in a shady lawyer; the DEA believes it has a line on the mysterious and elusive "Heisenberg"; Hank's stint in El Paso is up and he returns to Albuquerque, but his mental makeup causes concern for Marie.

After undergoing a PET-CAT scan and fearing the worst, Walt takes lawyer Saul's advice and hunkers down for a marathon session of cooking product; Jesse's romance with his landlady is heating up, but must cool off quickly when he and Walt head for the desert to take care of business.

Saul suggests a new business partner for Walt and Jesse after they begin to lose their dealers to some unforeseen circumstances. At work, Skyler confronts Ted after she uncovers some unnerving information; and Jesse opens up to Jane about what he does for a living, with disastrous results.

A new addition joins the White family as Walter Jr. attempts to help out his struggling family by launching a new Web site. Elsewhere, Jesse's addiction worsens and his relationship with Jane begins to negatively impact Walt and her father.

In the Season 2 finale, Skyler's frustration with Walt's secrecy boils over; Jesse is dealt a devastating blow that leads him down a path of self-destruction, and only Walt is willing to help him; and a grief-stricken Donald experiences more tragedy.

Despite ever-increasing tension between Walt and Skyler, he pulls out all the stops in an effort to reconcile with the family. Elsewhere, Saul is instrumental in getting Jesse involved in a most-unusual investment opportunity.

Skyler's latest bit of bad news proves to be a blow to Walt, and his loss of control endangers his job and his business relationships with Saul and Jesse. Hank goes full-speed ahead into the agency's investigation of the blue-meth case, while Jesse cooks up a new plan.

When Gus intensifies efforts to persuade Walt to get back in the meth business, Jesse takes exception and a rift appears in his and Walt's personal relationship. Meanwhile, Skyler's new relationship isn't turning out as she'd like; and Marie tells Skyler about her concerns for the increasingly troubled Hank and his well-being.

The White and Schrader families anxiously await word on Hank's condition. Meanwhile, Jesse takes care of business at the lab while Walt tries to make peace with Gus, but after witnessing a terrifying flash of anger, Walt starts to fear for his and his family's lives.

Hank's stay in the hospital is accompanied by some daunting bills, but Skyler thinks she has a way of dealing with them. Meanwhile, some of the problems between Walt and Gus are ameliorated; and Jesse seeks more independence and grabs a profitable opportunity that presents itself.

When Walt becomes driven to distraction by a contaminant in the lab, he refuses to cook meth until they are able to get rid of it.

Skyler's increased involvement in Walt's business causes him concern; Hank's recovery is plagued by setbacks; and Jesse makes a surprising discovery as he gets more involved in his new enterprise.

Jesse ignores Walt's advice and finds himself in a dangerous situation. Fearing for Jesse's safety, Walt takes drastic measures to try to put things right. And tragedy strikes following an unexpected confrontation.

Jesse goes on the lam in the third-season finale. But Mike is right on his heels, so Walt works a deal with Gus and comes up with an unsettling plan that might help guarantee both his and Jesse's safety.

In the Season 4 opener, Walt and Jesse are confronted by the life-threatening consequences of their actions. Meanwhile, Skyler contends with a puzzling disappearance, and Marie finds it difficult to help a recovering Hank.

Walt tries to establish a new alliance as he plots his next move. Meanwhile, Skyler urges Walt to consider a business opportunity that could keep the family safe.

Goings-on at Jesse's place start to get out of control; Skyler reluctantly turns to Saul for help; Marie settles back into an old habit; and Hank hears from an old friend who needs assistance.

The Cartel makes a power move; Skyler and Walt reveal something embarrassing to the family; and Jesse's misdeeds bring some unwanted attention.

Jesse's disappearance leaves Walt fearing the worst; Skyler has a surprising reunion; and Hank gives Det. Roberts bad news.

A shocking discovery unsettles Skyler; Walter Jr. leans on his father to make a special purchase; Mike gets surprise help from Jesse.

A frustrated Walt takes on a risky gamble; Skyler encounters problems with her latest business venture; Hank requires Walter Jr.'s services for an unusual reason.

Skyler devises a plan to cure her money woes; Hank recruits Walt to help him work out a theory, while Walt grows impatient with Jesse.

Mistakes from Skyler's past prove to be impactful to the present; Gus is spurred to action against rivals; Jesse seeks help from Walt but the results are mixed.

The family becomes gravely concerned when Walt doesn't show up for his son's 16th birthday celebration. And Jesse's lab skills are tested in Walt's absence.

Hank leans on Gomez to explore one final lead, as Walt scrambles to protect his family. Meanwhile, Jesse learns some unsettling news and races to share it with Walt.

The fourth season ends with Walt and Jesse squaring off against Gus. Elsewhere, Walt acquires a surprise confederate with help from Saul.

In the series 5 premiere, Walt deals with the aftermath of the explosion, while Hank wraps up his investigation of Gus and his criminal empire.

Walt and Jesse seek out an unlikely partner for a new business venture. The DEA follows up new leads in its investigation.

Walt and Jesse put a business plan into action. Walt confesses a secret to Marie.

Walt celebrates another birthday. Skyler considers her options. An associate complicates Walt and Jesse's plan.

Walt's team must get creative to obtain the materials they need to continue their operation.

Walt, Jesse, and Mike struggle over the future of their business, as occupational hazards weigh on Jesse.

Walt takes control of business matters as Mike grapples with the consequences of his actions.

As Walt and Jesse adjust to life out of the business, Hank grapples with a troubling lead.

Jesse decides to make a change, while Walt and Skyler try to deal with an unexpected demand.

An unusual strategy starts to bear fruit, while plans are set in motion that could change everything.

Things heat up for Walt in unexpected ways.

Everyone copes with radically changed circumstances.

The acclaimed crime drama comes to a close in the series finale.